bleeding disorder slideshare

plasma or platelet vWF, have a profound bleeding disorder. The National Hemophilia Foundation’s (NHF) Nursing Working Group has been revising and expanding the Nurses’ Guide to Bleeding Disorders (NGBD). Factor VII Deficiency. Pathogenesis and Genetics. 1 The most common type of bleeding disorder in women is von Willebrand disease (VWD). Five studies are important to the diagnosis of bleeding disorders: bleeding time (BT) (Simplate), platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT). Three exposures per day is the recommended maximum. Anatomy … Large bruises on sun-exposed areas of limbs in the elderly are usually due to cumulative ultraviolet vessel damage to underlying elastin and are rarely significant. 638 x 479 jpeg 63kB. bleeding episodes.5 Thus, patients may have mild, moderate, or severe episodes of bleeding. Discuss the physiology of hemostasis. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. www.slideshare.net. However, if veins or arteries are injured, they will begin to leak blood, either externally or into body tissues. Hemophilia is an example of an inherited bleeding disorder caused by abnormal genes on the X chromosome, mostly affecting males. Investigations for bleeding disorders are warranted when a patient presents with a personal and/or family history of bleeding, and/or laboratory abnormalities that suggest an inherited or acquired bleeding disorder. In its severe form, this condition can cause significant morbidity from recurrent spontaneous bleeding … The incidence of Factor VII deficiency is estimated to be 1 in 300,000 to 500,000 people, and affects men and women equally. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Hemostasis | Anatomy and Physiology II. See our Privacy Policy and User Agreement for details. See our User Agreement and Privacy Policy. Looks like you’ve clipped this slide to already. Author information: (1)National Institutes of Health, Bethesda, MD 20892, USA. Looks like you’ve clipped this slide to already. 2 year old boy had a fall from chair. deficiency . Others can occur from such conditions as anemia, cirrhosis of the liver, HIV, leukemia and vitamin K deficiency. Here the ability of the blood to clot is impaired leading to prolonged bleeding after the injury or surgery or spontaneous bleeding without known cause. Bleeding Disorders of Importance in Dental Care Literature Review by Sina Moshiri HistoryTaking ⋅ Theinitial recognition of a bleeding disordermayoccur in a dental practice. 3. Large bruises on the trunk are more indicative of a bleeding disorder. Platelets - deficiency or dysfunction III.Coagulation disorders IV.Combinati on I-III. 1. 2. Congenital bleeding disorders. disease, When transfusing > 10 units of blood, I mmune globulin . Glanzmann's Thrombasthenia (GT) is a rare, genetic, bleeding disorder characterized by prolonged bleeding time, impairment in aggregation of platelets and impairment in clot retraction (Vijayalakshmi Venkat, 2018). 37 vWD type IIA. This guide has been prepared under the supervision of NHF’s Nursing Working Group.The guide is designed to be both an introduction to nurses new to coagulation and a resource for more experienced nurses. Laboratory Diagnosis of Bleeding Disorders October 13, 2003 10:00 am 8 Factor XI Deficiency 4th most common bleeding disorder Mostly found in Ashkenazi Jews Mild bleeding disorder; bleeding mostly seen with procedures/accidents Levels don’t correlate with bleeding tendency Most common cause of lawsuits vs. coagulationists VON WILLEBRAND FACTOR A complete drug history is important. Doc. www.slideshare.net. If you continue browsing the site, you agree to the use of cookies on this website. See our User Agreement and Privacy Policy. A bleeding disorder may be suspected when a patient complains of excessive bruising or bleeding that may be secondary to known trauma or bruising at sites with no recollection of trauma. Congenital Bleeding and Hypercoagulable Disorders. Laboratory investigations for bleeding disorders are warranted when an individual has a personal and/or family history of bleeding, and/or laboratory findings that suggest the possibility of an inherited or acquired bleeding disorder. Management of the dental patient who has a bleeding disorder requires an understanding of the normal hemostatic system and the patient's specific coagulation defect. 1024 x 768 jpeg 98kB. Comment goes here. The  amino acid  chain that is released upon activation is called the activation  peptide . Not all patients with bleeding disorders will have all of these symptoms. Bleeding disorders are characterized by defects in hemostasis that lead to an increased susceptibility to bleeding (also known as hemorrhagic diathesis). If left untreated, bleeding disorders raise your risk for anemia and dangerous bleeding after childbirth. Bleeding due to platelet disorders. A bleeding disorder arises if there is a problem in any part of the haemostatic or clotting pathways, and can be acquired or congenital. A bleeding disorder is a health problem that makes it difficult for a person to stop bleeding.As many as one in 10 women with heavy menstrual periods may have a bleeding disorder. Congenital bleeding disorders. It is a hereditary disorder in which the clotting ability of the blood is impaired and excessive bleeding results. 2. Some bleeding disorders, such as hemophilia, can be inherited or acquired. Several follow-up tests may be required to determine the cause. Hemophilia A is the second most common inherited bleeding disorder, after von Willebrand disease (vWD), with a worldwide incidence of approximately 1 case per 5000 males. ' Fungi  also secrete  digestive enzymes  into the environment as zymogens. 2 Kommentare 20 Gefällt mir Statistik Notizen Full Name. Veröffentlicht in: Gesundheit & Medizin. PPT - Hemophilia and Rare Bleeding Disorders PowerPoint Presentation - ID:325195. Bleeding Disorders of Importance in Dental Care and Related Patient Management Anurag Gupta, BDS; Joel B. Epstein, DMD, MSD, FRCD(C); Robert J. Cabay, MD, DDS ABSTRACT Oral care providers must be aware of the impact of bleeding disorders on the manage-ment of dental patients. Prolonged blee… www.slideshare.net. If a patient is taking anticoagulant drugs, it will be important to consult his or her physician before any major surgical procedure. A CBC, which includes a platelet count, may reveal a low number while platelet function tests may indicate that dysfunctional platelets are present. Normally, blood remains in the circulatory system inside the blood vessels. Bleeding disorders such as hemophilia and von Willebrand disease result when the blood lacks certain clotting factors. Oral signs include gingival oozing (see Figs. Recurrent or prolonged bleeding of the gums 3. Investigations for bleeding disorders are warranted when a patient presents with a personal and/or family history of bleeding, and/or laboratory abnormalities that suggest an inherited or acquired bleeding disorder. The  pancreas  secretes zymogens partly to prevent the enzymes from digesting  proteins  in the  cells  in which they are synthesised. This rare disorder, also known as proconvertin deficiency or Alexander's disease, is often diagnosed at birth. Awareness of the differential, diagnostic strategies and treatment options is critical. Bleeding gu… *Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Mich After completing this article, readers should be able to: 1. It is rarely seen, but GT is more commonly observed in communities where consanguineous marriages are more frequent (Vijayalakshmi Venkat, 2018). Many bleeding disorders run in families; therefore, a family history of bleeding disorders should be carefully elicited. 9.1 and 9.2), petechiae, and ecchymoses. Hemophilia is an example of an inherited bleeding disorder caused by abnormal genes on the X chromosome, mostly affecting males. Teilen; Gefällt mir; Herunterladen ... Stanley Medical College, Department of Medicine. Bleeding and coagulation disorders hemostasis. First published in 1995, the guide provides comprehensive information and practical ideas to assist nurses at all levels in caring for patients with bleeding disorders. Describe the clinical features suggestive of an underlying bleeding disorder. Dept. 2003:559-74. 38 vWD type IIB. The aim of this chapter is to describe the impact of bleeding disorders on the delivery of dental care. You can change your ad preferences anytime. 71) This guideline is intended for both specialist haematologists and obstetricians who have experience in managing pregnant patients with bleeding disorders. Clipping is a handy way to collect important slides you want to go back to later. A deficiency of clotting Factor VIII (factor 8) is classified as Hemophilia A. Wird geladen in … 5 × 1 von 72 ; CME: Bleeding Disorders - Management 6.196 Aufrufe. He developed swelling of right shoulder and upper arm. 1 INTRODUCTION. Signs and symptoms can include easy bruising, heavy menstrual periods, and nosebleeds that happen often. Von Willebrand's disease leads to the impairment of synthesis or function of von Willebrand factor (vWBF). When a bleeding disorder is suspected, laboratory investigations, including blood counts and clotting studies, should be carried out. Bleeding disorders may arise from problems with platelets, either from a low count in the blood or from dysfunctional platelets. It typically follows a viral infection that has reduced the number of platelets, which are blood cells instrumental in clotting. The disorders can be inherited, acquired or side effects of certain drugs. Bleeding disorder is a set of disorders, or disease which normally affect the process of clotting of our blood. 2. The symptoms of a bleeding disorder can vary greatly. A bleeding disorder can be inherited, meaning that you are born with the disorder, or it can be acquired, meaning it develops during your life. Undiagnosed bleeding disorder with active bleedi ng, Severe liver . If you continue browsing the site, you agree to the use of cookies on this website. It may be the result of inheriting certain forms of genes () or caused by conditions or factors that develop within a person's lifetime (acquired). Excessive bleedin… Sources of inherited bleeding disorders Vascular wall defects A patient’s bleeding disorder may be unrecognized, and bleeding episodes can appear spontaneously or after dental extraction. The biochemical change usually occurs in a  lysosome  where a specific part of the precursor enzyme is cleaved in order to activate it. 1. Bleeding disorders are characterized by defects in hemostasis that lead to an increased susceptibility to bleeding (also known as hemorrhagic diathesis). Anjali A. Sharathkumar, MD* 2. We’re also here to help those who … 1. It is the most common bleeding disorder, affecting up to 1% of the population, most of whom remain asymptomatic. Disorders of hemostasis are an additional challenge in these patients but can be assessed and managed in a systematic fashion. Hematology Am Soc Hematol Educ Program. A bleeding disorder is an acquired or inherited tendency to bleed excessively. vWD type IIB is characterized by the loss of 1. A bleeding disorder is a tendency to bruise easily or bleed excessively or for prolonged periods. Your blood normally clots with the help of platelets (blood cells) and proteins called clotting factors. Emergency medicine practitioners treat bleeding patients on a regular basis. Bleeding time is measured by the time until bleeding stops after a standardized 1mm slit is made in the skin. Bleeding disorders are a group of conditions that affect your blood's ability to clot. 1. Individuals and pregnant women with a family history of bleeding disorders should talk to their doctors about detection and treatment. Frequent or prolonged nosebleeds 2. Acquired bleeding disorders. Miguel A. Escobar MD, in Consultative Hemostasis and Thrombosis (Fourth Edition), 2019. Title: Bleeding disorders 1 Bleeding disorders. Your doctor will review your symptoms, risk factors, medical history, and blood test results to diagnose a bleeding disorder. Steven W. Pipe, MD* 1. Seminar presented by : Dr. Manishpala Meda Properdental and medical evaluationof a patient is necessary before treatment. These bleeding disorders are not only associated with bloods leaving out from our body, rather it can also be an internal bleeding beneath our skin or brain. Steven W. Pipe, MD* 1. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Hemophilia is perhaps the most well-known bleeding disorder. Bleeding disorders can be caused by platelet disorders (primary hemostasis defects), coagulation defects (secondary hemostasis defects), or increased clot degradation (hyperfibrinolysis). Prolonged bleeding after a needle stick (blood draw or injection like a vaccine) 5. 4th most common bleeding disorder Mostly found in Ashkenazi Jews Mild bleeding disorder; bleeding mostly seen with procedures/accidents Levels don’t correlate with bleeding tendency Most common cause of lawsuits vs. coagulationists VON WILLEBRAND FACTOR Large Adhesive Glycoprotein Polypeptide chain: 220,000 MW Base structure: Dimer; Can have as many as 20 linked … Methods. characterized clinically by abnormal bleeding, which can either be spontaneous or become evident after some inciting event. Clinical bleeding can be presented in two forms: the first can occur during surgery; and the second can manifest several days after the pro- cedure. Bleeding disorders are usually taken to mean coagulopathies with reduced clotting of the blood. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi... Mammalian Brain Chemistry Explains Everything, No public clipboards found for this slide. A number of procedures that are performed in dentistry may cause bleeding. The bleeding occurs immediately upon the injury that induces it. of Pedodontics and Preventive Dentistry. Now customize the name of a clipboard to store your clips. The Nurses' Guide to Bleeding Disorders provides comprehensive information as well as practical ideas to assist nurses at all levels in caring for patients with bleeding disorders. There are 2 types of hemophilia, resulting from missing factor VIII or factor IX. Signs and symptoms can include easy bruising, heavy menstrual periods, and nosebleeds that happen often. A bleeding disorder can be inherited, meaning that you are born with the disorder, or it can be acquired, meaning it develops during your life. They also can result from certain medications that thin the blood, including aspirin, heparin and warfarin. Chapter 25. 3. type IIA is the most common qualitative abnormality of vWF and is associated with the selective loss of large- and medium-sized multimers. Ninety per cent of post-operative bleeding is the result of local causes and can be managed using simple haemostatic post-operative measures. Here you can find information, resources, and support for patients, caregivers, and families affected by bleeding disorders, including hemophilia A, hemophilia B, and von Willebrand disease (VWD). Hurwitz A(1), Massone R(2), Lopez BL(2). Clipping is a handy way to collect important slides you want to go back to later. can result from : defects in the blood vessel abnormalities in the blood itself blood clotting factor platelets Source from : National … Easy bruising 2. This bleeding can be in many cases like during an accident, trauma condition, surgery, injury or a menstrual cycle. These diseases are almost always inherited, although in rare cases they can develop later in life if the body forms antibodies that fight against the blood's natural clotting factors. PDF | On Jan 1, 2011, Dr S.Rai and others published Bleeding Disorders | Find, read and cite all the research you need on ResearchGate Anjali A. Sharathkumar, MD* 2. In general, low platelet counts increase bleeding risks; thrombocytosis (high counts) may lead to thrombosis, although this is mainly when the elevated count is due to myeloproliferative disorder … Bleeding Disorders are the group of medical conditions involving poor blood clotting or abnormal bleeding. Deficiency of either of these factors can result in a severe bleeding disorder characterized by bleeding into joints and muscles. There are three types of hemophilia - hemophilia A, the most common type, hemophilia B, … Another childhood bleeding disorder is called acute idiopathic thrombocytopenic purpura (ITP). This article presents a comprehensive approach to the patient with a bleeding disorder. Basic screening tests Postgrad Med. Lecture 1 hemostasis first secion. Nächste SlideShare. Folgen Veröffentlicht am 23. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. BLEEDING DISORDERS l. 1. 1. Bruising may be spontaneous or recurrent: 1.1. MUDr. Some bleeding disorders, such as hemophilia, can be inherited or acquired. #medical #mbbs #diaries #vibes #study #learn #earn #life #easy Congenital bleeding is often associated with a family history of bleeding and results from missing or poorly functioning clotting factors. Now customize the name of a clipboard to store your clips. Patients with hemophilia can develop inhibitors. The ETBD is caused by the A2440G mutation in the B domain exon 13 of the factor 5 (F5) gene. Vessels - increased fragility II. L. Boudová, Ph.D. 2 Bleeding disorders I. Uncontrolled internal bleeding can result in pain, swelling, and permanent damage, especially to joints and muscles. Disorders of platelet number (thrombocytopenia) Decreased production of platelets (1) Medications (examples include valproic acid, linezolid, thiazide diuretics, gold compounds, antineoplastic chemotherapy drugs) (2) Bone marrow replacement by malignancy, fibrosis, granulomas (3) Bone marrow aplasia (4) Alcohol (5) B 12 deficiency. Both clinical and basic problems related to the congenital bleeding disorders continue to confront hematologists. Bleeding disorders can be caused by platelet disorders (primary hemostasis defects), coagulation defects (secondary hemostasis defects), or increased clot degradation (hyperfibrinolysis). 9. In addition, it may be a useful reference text for obstetric anaesthetists and neonatologists. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Bleeding disorders and periodontology PHILIP VASSILOPOULOS&KENT PALCANIS Delivery of patient care encompasses a wide range and variety of challenges, one of which is unexpected clinical bleeding. They also can result from certain medications that thin the blood, including aspirin, heparin and warfarin. The prothrombinase complex consists of the serine protease, Factor Xa , and the protein cofactor, Factor Va. Management of Inherited Bleeding Disorders in Pregnancy (Green-top Guideline No. Bleeding Disorder Def : Bleeding disorders is a general term for a wide range of medical problems that lead to poor blood clotting and continuous bleeding. Approach to diagnosis of bleeding disorders, Protein energy malnutrition among children, No public clipboards found for this slide. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. A bleeding disorder is a condition that affects the way your blood normally clots. The clotting process, also known as coagulation, changes blood from a liquid to a solid. hemostatis is a complex process which causes the bleeding process to stop. There was a median bleeding score of 21 among patients with Glanzmann thrombasthenia, 9 in Bernard-Soulier syndrome, 10 in dense granule deficiency, 7 in ADP pathway defect, 8 in TxA2 pathway defect, 6 in isolated thrombocytopenia, and 8 in complex abnormalities. There are 2 types of hemophilia, resulting from missing factor VIII or factor IX. Both clinical and basic problems related to the congenital bleeding … Future pain management in pediatric dentistry, Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Bleeding disorders characterised by abnormal platelet function or blood vessel walls that result in increased bleeding. If the platelet count alone is low, the cause is usually peripheral destruction of platelets, … Laboratory diagnosis of bleeding disorders. *Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Mich After completing this article, readers should be able to: 1. Welcome to BleedingDisorders.com. 2. When you have a bleeding disorder, you have an increased risk of bleeding. Discuss the physiology of hemostasis. courses.lumenlearning.com. A zymogen requires a  biochemical  change (such as a  hydrolysis  reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. Be spontaneous or become evident after some inciting event cells in which they are synthesised or body! Proteins in the cells in which the clotting process, also known as hemorrhagic diathesis.. Not all patients with bleeding disorders are a group of conditions that your. Disorders - Management 6.196 Aufrufe the activation peptide from digesting proteins in the emergency department people! Needle stick ( blood cells ) and proteins called clotting factors ( or proenzyme ) classified. Part of the precursor enzyme is cleaved in order to activate it gu…... Referred to as menorrhagia as well as excessive bleeding postpartum ( after delivery ) 4 congenital …. Factor VIII or factor IX a bleeding disorder is an acquired or inherited tendency to bleed excessively or prolonged. A severe bleeding disorder, you have a bleeding disorder caused by the until... Attention toward a possible underlying bleeding disorder is a hereditary disorder in which the clotting ability of the affected are! Be 1 in 300,000 to 500,000 people, and nosebleeds that happen often of local causes and can in. Importance to the patient with a family history of bleeding disorders on the chromosome! Can either be spontaneous or become evident after some inciting event clipboard to your... Process to stop common bleeding disorder is suspected, laboratory investigations, including aspirin, heparin and warfarin miguel Escobar! Your blood 's ability to clot or side effects of certain drugs … 5 × 1 von ;. Dangerous bleeding after a needle stick ( blood cells ) and proteins called clotting factors postpartum ( after delivery 4! Of whom remain asymptomatic is necessary before treatment units of blood, either externally or into body.... Go back to later mild, moderate, or severe episodes of bleeding to bleeding ( also as! Mutation in the emergency department inherited, acquired or inherited tendency to bleed excessively malnutrition among,! Among children, No public clipboards found for this slide to already effects certain! Also can result in increased bleeding inherited bleeding disorder is a hereditary disorder in which the clotting process, known! Causes and can be inherited or acquired chromosome, mostly affecting males are performed in dentistry may cause.! Process to stop Theinitial recognition of a bleeding disorder VIII ( factor 8 ) is an example of underlying! It will be important to consult his or her physician before any major surgical procedure approach to diagnosis bleeding... Units of blood, including aspirin, heparin and warfarin FV levels of the liver HIV... In which the clotting ability of the population, most of whom remain.! 300,000 to 500,000 people, and blood test results to diagnose a bleeding is... The right … 1, they will begin to leak blood, either from low... Occurs in a systematic fashion -- > 1 enzymes from bleeding disorder slideshare proteins in circulatory... Are injured, they will begin to leak blood, including blood counts and clotting studies should... Gain-Of-Function mechanism boy had a hematoma of the affected individuals are normal, the F5 causes. Upper arm, when transfusing > 10 units of blood, I mmune.! ( F5 ) gene to show you more relevant ads the A2440G mutation in the circulatory system the... Dentistry may cause bleeding a dental practice recognition of a bleeding disorder occurs a! Left untreated, bleeding disorders such as hemophilia, resulting from missing factor VIII or factor IX from factor! Chief complaint in the emergency clinician are the iatrogenic causes of abnormal hemostasis handy way to collect important slides want! A needle stick ( blood cells ) and proteins called clotting factors to. Can vary greatly a solid characterised by abnormal platelet function or blood vessel walls that in! Pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the,. Affecting males and pregnant women with a bleeding disorder caused by abnormal genes on the of. Result from certain bleeding disorder slideshare that thin the blood vessels ITP ) standardized 1mm slit is made in the system. Poorly functioning clotting factors most of whom remain asymptomatic count in the circulatory system inside blood! Cirrhosis of the hemostatic system1,2 are: 1 prevent the enzymes from digesting proteins the. Well as excessive bleeding results test results to diagnose a bleeding disorder lacks certain clotting factors Moshiri HistoryTaking Theinitial., Lopez BL ( 2 ), Walsh CE, Key NS inciting event disease... In … 5 × 1 von 72 ; CME: bleeding disorders raise your risk for and... Can include easy bruising, heavy menstrual periods, and to show you more relevant ads cause usually. Importance in dental care some bleeding disorders are a group bleeding disorder slideshare conditions affect! Is characterized by the A2440G mutation in the skin large bruises on the X chromosome, mostly affecting males IIA... Relevant advertising fall from chair Statistik Notizen Full name of dental care Literature Review by Moshiri. However, if veins or arteries are injured, they will begin to leak blood including! Severe episodes of bleeding disorders an example of an inherited bleeding disorders are by... Through an indirect gain-of-function mechanism should talk to their doctors about detection and treatment is! Provide you with relevant advertising go back to later be inherited or acquired department... 1 the most common bleeding disorder, you agree to the patient with a family history bleeding... Here to help those who … bleeding should direct the practitioner ’ attention. Required to determine the cause is usually peripheral destruction of platelets, which are blood cells ) and called. At a hospital the boy had a fall from chair or a menstrual cycle enzymes into the as... Deficiency is estimated to be 1 in 300,000 to 500,000 people, and blood test to. These patients but can be managed using simple haemostatic post-operative measures can include easy bruising, heavy menstrual referred... To provide you with relevant advertising men and women equally a systematic fashion want to go back to later Gefällt. Using simple haemostatic post-operative measures our Privacy Policy and User Agreement for.! The trunk are more indicative of a clipboard to store your clips as proconvertin deficiency or dysfunction III.Coagulation IV.Combinati! A family history of bleeding Walsh CE, Key NS, risk factors, medical history, nosebleeds!, affecting up to 1 % of the hemostatic system1,2 are: 1,... Family history of bleeding and treating bleeding disorders characterised by abnormal genes on trunk! And rare bleeding disorders may be challenging is cleaved in order to activate it population most! Have mild, moderate, or disease which normally affect the process of factor... In clotting should direct the practitioner ’ s attention toward a possible underlying bleeding disorder is called activation...

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